The high lord messiah and supreme ruler of the Terran Empire, Lord Erion Bael IX, has commanded Augustus Winn (a.k.a. The Mindtaker), to create the ultimate weapon. The device is a human hybrid quantum supercomputer, designed to calculate all future probabilities and destinies and would allow Lord Bael the ability know the thoughts and outcomes of all events and to crush any who would oppose him.

To develop this weapon for his lord, Augustus discovers he needs genetic markers from specific human DNA, to use in his experiments. To obtain the raw materials for this great mission from his Lord, Augustus assigns the task of overseeing the extraction of the human specimens to Winston (a.k.a The General), the most trusted warrior servant of Lord Bael. Led by General Winston, the Soundkeepers, hunter-seekers of the Terran Empire, are sent to abduct the needed human subjects. Once they have harvested the needed genetic material from the human subjects' DNA, they are quickly returned to their lives. Soon, these humans develop side-effects that spread into an epidemic that threatens the entire world.

Darius Santos (a.k.a Uri Khan), the founder of the private military services firm, BILT Corp, is a highly intelligent scientist. He and his unique team will soon have to come face to face with the adjusted humans and those behind this plague, or accept the next phase of human evolution
may be those who have become… The Adjusted!